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On April 6, 1901, in the maternity ward of a hospital on the Lower East Side of New York City, Samuel Abramov - the one and only child of Lev and Raisa Abramov - is born.

"Sam in New York" follows Sam's life from his elementary school years to his late twenties, as he deals with his overbearing, demanding parents' desire for him to be a lawyer, his burgeoning love for the theatre, and embarks on his unceasing quest for fame, love and acceptance.