The Pistol does only a small amount of damage per hit. However, its high rate of fire makes its overall damage output relatively substantial if multiple consecutive shots are landed. In addition, its accuracy, while not entirely exceptional, is superior to that of the Scattergun or Shotgun. This makes it useful for fights that take place outside of the primary weapon's effective range, to finish off retreating targets, or as a backup weapon when the primary weapon is out of ammunition. The accuracy also makes it ideal for destroying Stickybombs and taking out unsupervised Sentry Guns outside their firing range.

Upon ingestion, Crit-a-Cola gives the Scout the ability to deal mini-crits for 8 seconds with any equipped weapon. However, making any attack while under the effect immediately causes a 5 second Marked-For-Death debuff. Making additional attacks while this debuff is active will reset its duration.

Upon ingestion, Bonk! Atomic Punch renders the player invulnerable for 8 seconds. During this time, the player is forced into third-person mode and may not attack with any weapon, being limited to actions such as moving, jumping, and reloading their weapons, with a blurry trail following them. While invulnerable, most things that would normally hurt the Scout instead produce a "Miss!" signal above his head, followed by one of many voice responses. A Scout cannot use Bonk! while carrying the Intelligence, or grab the Intelligence while still under the drink's effects. Scouts under the effects of Bonk! can neither capture nor defend objectives such as control points or Payload carts. The player has unlimited Bonk! cans at their disposal, but cannot take out another can until the item's cooldown period, shown in the HUD, is over. The effects of Bonk! cease if a Scout using it activates a Resupply locker.

While under the effects of Bonk!, the player is immune to almost all forms of damage, including direct damage, residual damage, self-inflicted damage, and fall damage. Damage-over-time effects, such as afterburn and bleeding, do not deal damage for the duration of the Bonk! effect, but continue when the drink wears off. However, on-hit effects (such as the Ubersaw's +25% ÜberCharge on hit) still take place if they are not based on the amount of damage dealt (such as the Buff Banner's rage meter), and Bonk! provides no protection from knockback, environmental damage, or telefrags.

After the effect ends, the player receives a 5-second slowdown based on the amount of damage they absorbed while invulnerable. The slow effect scales from 25% at low damage up to 50% after absorbing 200+ damage. The Baby Face's Blaster does not affect the slowdown penalty.

The Electric Twanger is a Stock Reskin of the Scout's default Bat.

In addition to sharing the attack speed and damage of the normal Bat, pressing alt-fire (default key: MOUSE2) with the Sandman causes the Scout to launch the baseball towards the enemy. Successfully hitting a target with the baseball slows the enemy as well as damages them, provided that they are a sufficient distance away. A slowed enemy's speed is capped at 225.88 Hammer units per second (about the same speed as a walking Heavy), regardless of the class. The slow duration depends on how long the ball has been in the air; the longer the ball's travel time, the longer the victim is slowed, ranging from 1 to 7 seconds. If the enemy is hit with a baseball that has traveled for sufficiently long, the victim suffers a moonshot, identifiable by a cheering audience sound clip, and is slowed for the maximum slow duration. If the Scout launches the ball short of the minimum slow distance, the ball hits and inflicts minor damage, but bounces off the enemy with no effect. The Scout is also only equipped with one baseball, which reloads after a 10-second interval indicated in the cooldown bar on the HUD. Despite being a projectile, the baseball is considered a melee weapon, meaning it uses the higher critical chance of melee weapons and deals double damage to Heavies that have the Fists of Steel active.

Baseballs can be picked up off the ground, whether owned by the player or another Scout, or by visiting a Resupply locker. Baseballs are not classed as ammunition and thus cannot be retrieved by picking up (dropped) ammo packs. A baseball that does not hit an enemy remains on the ground and disappears after 10 seconds, effectively the time it takes the Scout to gain a new one. After slowing an enemy, it disappears much more quickly - after about three seconds - but can still be picked up and used again if acquired before it disappears. As a projectile, the ball arcs towards the ground and can be deflected by an enemy Pyro. The ball can also hit and bounce off of enemy grenades, Jarate, Mad Milk, and even enemy Scout baseballs.

Scouts carrying the Sandman lose 15 max health points, lowering their base health to 110. The weapon is therefore suited to support tactics, as it places the player at greater risk of death during combat. The maximum possible overheal is also reduced to 165 HP and 139 HP from the Quick-Fix.

The Atomizer grants the wielder the ability to triple jump while the weapon is fully deployed. When performing a triple jump with the Atomizer active, a cloud of purple smoke trails behind the Scout, as opposed to the normal white cloud. Also, while airborne, attacks with this weapon deal mini-crits. As a downside, the Atomizer has a 50% deploy time penalty and deals 15% less damage to players. However, it does the same amount of damage as the Bat to non-player objects such as buildings.