Axme's pretty quirky. She's very dedicated to her job and the process of scientific discovery, even if her idea of scientific discovery means violating ethical guidelines. Outwardly most see her as a bit eccentric and nerdy. Anything she says that alludes to her more dubious nature or seems suspicious is usually just passed off as a joke.

Axme's intelligence and scientific knowledge mostly pertains to biology and chemistry. She specializes in medicine, usually taking the form of potions that can somehow heal almost any ailment someone could have, and sometimes even make them feel even better than they were beforehand. Dr. Axme is a little haphazard with her experiments though, which has often led to accidents, including one which created a brand new lifeform. If you see that big scary version of her in the reference image, that too was a result of a failed experiment.