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Adrian has always been hardworking and of a stoic nature. She was never one to enjoy working with peers though on the other hand, she never tried to rock the boat. The demeanor she portrayed was one of someone who was serious about her work and it came with the respect of those around her.
She was deeply invested in her career and helping others with her medical prowess is still something she cared about greatly. Though, a friend's terminal diagnosis changed her methods of showing this. Her reculse nature increased two-fold and, even though she was never one to actively seek out others, her friends noticed a decline in the times they would see her at an outing.
Adrian finally came out of her lab with a self-proclaimed miracle cure; her excitment to present it to her friend was unparalleled. Meeting up with them after the long amount of time that had past didn't seem wrong to her and everything went well in her eyes until her cure was declined.
Even before her friend rejected her, Adrian was a recluse. This trait only became magnified after the fact as she threw herself into perfecting her miracle cure over anything else. The lengths that she would go through kept stretching further and further and eventually, it seemed that she had lost all sense of morals.
She's a woman of few words now. If she has to talk to anyone, it's mostly just GenesOS and Belair. Even with patients that come to her she'll try to work off-hand; most of the time sending one of her two goons to do any face-to-face interactions.