Mana is a concept that is often used in fantasy fiction, particularly in stories that involve magic and mystical powers. In these contexts, mana is usually understood as a kind of spiritual or magical energy that exists within the natural world and can be harnessed by skilled practitioners to perform extraordinary feats.

In "Fight Me with Mana!" it's used to beat people senseless and get popular. Magic rules all. The power of mana is the key to victory in battles, and only the strongest and most skilled mages can hope to come out on top. A young delinquent called "Meathead" a young, navigates the dangerous world of mana-fueled combat. Raised in a city he's never had a natural talent for magic, he constantly loses and uses a mix of boxing and mana control for his fighting techneique. But that starts to change when he receives an invitation to compete in the prestigious Mana Battles, a tournament where the greatest mages from around the world come to test their mettle. Unknown to "Meathead" many other bad magicians were invited as a joke.