She briefly had an argument with Ko the first time she's seen but it was quickly stopped by Aki. Later on in te introduction arc, she shows some concern towards Romano who panics because of Ko. She's seen with Zuro after the meeting, and they were found talking with one another. She quickly gets tired of Ace and Zuro's conversationm making her leave to meet the other members of the group to tell an announcement.
Training Arc
Being a medic, her tutor was Yuri, who was a medic of Retribution. Throughout the scenes, Yuri and Sepheir talk about one another and hint some of their thoughts, but it has yet to show their full training conversations. During training, she had to patch up Zuro who gets injured because of a fight with Akira, and she comforts Zuro because of a sudden break down he had. By the end of the arc, she shows thanks to Yuri and shows that they both respect each other and were both glad that they were able to be with each other for training.
First Mission Arc
When the fight between Protezioni and Gli Dei end, Sepheir and her crew comes over to take the injured members back to help them with their injuries. Sepheir was inside the medic room, waiting for Tsuyobi and Tana to be in proper condition before she leaves to meet Romano. She reassures Romano that he's still amazing as he is and she still proud of him. After telling her feelings, she goes back to her assigned room and tells Zuro about how she felt, and she gets to talk to him later on. By the end of the arc, she's seen conversing with the capos, being one of the main people to calm down both Rika and Romano.