Gradient maps are great for getting transparent lineart for traditional lines.
Basically, after you do the page tweaks and clean-up (getting rid of scanner dust, upping the contrast/levels, line corrections) use a black to transparent Gradient map and boom. Lineart ready to color with no random white pixels, or needing to make it super pixel-y
wish I knew this earlier, would've made getting colored lines with tra-digital a lot easier
v On using off-white, I feel like I should add consider the pic, the usecase (or style) you're going for first. For example, I found using off-whites for pics with transparent backgrounds to make my artwork appear more muted than it should be on some displays, especially if the site it's on has a light mode or BG it could warp how you see the colors bc it's ever-so-slightly off. Though for scenes heavily affected by lighting, it could help keep the colors balanced or make certain colors 'pop' (eg: saving white for heavily lighted areas, or balancing it with the most dominant color). Though this is based off my own style & how I use my art so it might not apply to everyone